Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01324-0001-0000-3 |
Chemical Name: | 2-Ethylhexanoic acid |
CASRN: | 149-57-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 631517_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
No Activation | 2 | Positive |
No Activation | 3 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Induced Rat Liver S9 | 3_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1033 | 421 | 0.408 | 8.42 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 313 | 50 | 1036 | 457 | 0.441 | 9.14 | 26.0 | 8.237 |
Positive Control | Mitomycin-C | 0.0015 | 50 | 1022 | 672 | 0.658 | 13.44 | 26.0 | 61.338 |
Mitomycin-C | 0.01 | 5 | 105 | 238 | 2.267 | 47.60 | 26.0 | 456.168 | |
Trend: | 0.000 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1040 | 447 | 0.430 | 8.94 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 199 | 50 | 1040 | 794 | 0.763 | 15.88 | 26.0 | 77.629 |
301 | 50 | 1038 | 879 | 0.847 | 17.58 | 32.0 | 97.023 | ||
505 | 50 | 1043 | 1217 | 1.167 | 24.34 | 32.0 | 171.476 | ||
2500 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1036 | 670 | 0.647 | 13.40 | 26.0 | 50.467 |
Mitomycin-C | 0.01 | 5 | 105 | 190 | 1.810 | 38.00 | 26.0 | 321.008 | |
Trend: | 18.655 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1038 | 470 | 0.453 | 9.40 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 400 | 50 | 1038 | 648 | 0.624 | 12.96 | 34.0 | 37.872 |
500 | 50 | 1034 | 674 | 0.652 | 13.48 | 34.0 | 43.959 | ||
600 | 50 | 1024 | 728 | 0.711 | 14.56 | 34.0 | 57.011 | ||
700 | 50 | 1030 | 725 | 0.704 | 14.50 | 34.0 | 55.453 | ||
800 | 50 | 1024 | 778 | 0.760 | 15.56 | 34.0 | 67.795 | ||
1000 | 0 | 0 | 0 | 0.000 | 0.00 | 34.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1045 | 606 | 0.580 | 12.12 | 26.0 | 28.072 |
Mitomycin-C | 0.01 | 5 | 99 | 203 | 2.051 | 40.60 | 26.0 | 352.856 | |
Trend: | 8.865 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1024 | 471 | 0.460 | 9.42 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 9.38 | 50 | 1037 | 427 | 0.412 | 8.54 | 26.0 | -10.478 |
31.3 | 50 | 1044 | 465 | 0.445 | 9.30 | 26.0 | -3.165 | ||
93.8 | 50 | 1034 | 634 | 0.613 | 12.68 | 26.0 | 33.305 | ||
313 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1034 | 668 | 0.646 | 13.36 | 26.0 | 40.454 |
Cyclophosphamide | 2 | 5 | 105 | 183 | 1.743 | 36.60 | 26.0 | 278.914 | |
Trend: | 5.030 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1042 | 587 | 0.563 | 11.74 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 505 | 50 | 1045 | 620 | 0.593 | 12.40 | 26.0 | 5.319 |
753 | 50 | 1040 | 586 | 0.563 | 11.72 | 26.0 | 0.022 | ||
1000 | 50 | 1038 | 733 | 0.706 | 14.66 | 26.0 | 25.353 | ||
2500 | 50 | 1038 | 750 | 0.723 | 15.00 | 26.0 | 28.261 | ||
5200 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1043 | 699 | 0.670 | 13.98 | 26.0 | 18.966 |
Cyclophosphamide | 2 | 5 | 105 | 166 | 1.581 | 33.20 | 26.0 | 180.639 | |
Trend: | 5.319 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1031 | 414 | 0.402 | 8.28 | 26.0 | 0.000 |
Test Chemical | 2-Ethylhexanoic acid | 1000 | 50 | 1036 | 501 | 0.484 | 10.02 | 26.0 | 20.430 |
1500 | 50 | 1030 | 662 | 0.643 | 13.24 | 26.0 | 60.059 | ||
2100 | 50 | 1023 | 605 | 0.591 | 12.10 | 33.0 | 47.278 | ||
3000 | 50 | 1015 | 692 | 0.682 | 13.84 | 33.0 | 69.785 | ||
3500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1032 | 568 | 0.550 | 11.36 | 26.0 | 37.065 |
Cyclophosphamide | 2 | 5 | 103 | 161 | 1.563 | 32.20 | 26.0 | 289.266 | |
Trend: | 9.104 | ||||||||
Probability: | 0.000 |