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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01215-0009-0000-0 |
Chemical Name: | 2,4-Diaminoanisole sulfate |
CASRN: | 39156-41-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | G63131 |
Study Result: | Positive |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
96 | 92 | 129 | 45 | 48 |
87 | 93 | 136 | 52 | ||||
Test Chemical | 2,4-Diaminoanisole sulfate |
3.93 |
73 | 78 | 116 | 53 | 46 |
84 | 108 | 97 | 38 | ||||
7.87 |
90 | 94 | 133 | 49 | 49 | ||
72 | 92 | 105 | 49 | ||||
15.7 |
73 | 71 | 128 | 58 | 55 | ||
82 | 68 | 127 | 52 | ||||
31.5 |
97 | 58 | 216 | 75 | 86* | ||
77 | 58 | 223 | 97 | ||||
63 |
82 | 18 | 467 | 190 | 238* | ||
60 | 17 | 516 | 287 | ||||
126 |
|||||||
Positive Control | Ethyl Methane Sulfonate |
500 |
39 | 28 | 814 | 696 | 664* |
43 | 27 | 809 | 632 | ||||
Negative Control | Negative (Not Specified) |
0 |
98 | 99 | 101 | 34 | 34* |
97 | 115 | 96 | 33 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
92 | 93 | 64 | 23 | 21 |
96 | 108 | 52 | 18 | ||||
Test Chemical | 2,4-Diaminoanisole sulfate |
20 |
78# | 69 | 64 | 27 | 29 |
69# | 69 | 63 | 31 | ||||
40 |
94 | 52 | 124 | 44 | 46* | ||
89 | 61 | 130 | 49 | ||||
60 |
85 | 27 | 246 | 97 | 103* | ||
83 | 27 | 273 | 109 | ||||
100 |
65 | 5 | 514 | 264 | 232* | ||
52 | 3 | 312 | 201 | ||||
Positive Control | Ethyl Methane Sulfonate |
500 |
82 | 64 | 542 | 221 | 282* |
68 | 47 | 701 | 344 | ||||
Negative Control | Negative (Not Specified) |
0 |
97 | 95 | 50 | 17 | 23* |
82 | 105 | 69 | 28 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
99 | 79 | 67 | 23 | 17 |
103 | 118 | 48 | 16 | ||||
94 | 108 | 40 | 14 | ||||
103 | 95 | 45 | 15 | ||||
Test Chemical | 2,4-Diaminoanisole sulfate |
12.5 |
96 | 77 | 122 | 43 | 41* |
83 | 82 | 98 | 40 | ||||
25 |
96 | 52 | 181 | 63 | 83* | ||
72 | 39 | 223 | 104 | ||||
50 |
64 | 9 | 285 | 150 | 153* | ||
66 | 15 | 307 | 156 | ||||
75 |
32 | 3 | 430 | 446 | 427* | ||
27 | 2 | 386 | 482 | ||||
31 | 2 | 331 | 354 | ||||
100 |
|||||||
Positive Control | Ethyl Methane Sulfonate |
500 |
32 | 13 | 751 | 778 | 734* |
36 | 23 | 785 | 737 | ||||
40 | 22 | 822 | 688 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
91 | 105 | 111 | 41 | |
Test Chemical | 2,4-Diaminoanisole sulfate |
0.975 |
88# | 100 | 88.5 | 34 | 37 |
103 | 103 | 123 | 40 | ||||
1.95 |
100 | 108 | 165 | 55 | 51 | ||
96 | 117 | 136 | 47 | ||||
3.9 |
83 | 80 | 182 | 73 | 70 | ||
82 | 91 | 163 | 66 | ||||
7.8 |
90 | 61 | 206 | 77 | 76* | ||
98 | 76 | 223 | 76 | ||||
15.6 |
96 | 66 | 235 | 81 | |||
Positive Control | 3-Methylcholanthrene |
5 |
70 | 34 | 765 | 364 | 357* |
64 | 37 | 675 | 350 | ||||
Negative Control | Negative (Not Specified) |
0 |
78# | 98 | 96 | 41 | 43* |
96 | 97 | 131 | 45 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
64 | 87 | 127 | 66 | 69 |
82 | 124 | 143 | 58 | ||||
98 | 114 | 186 | 63 | ||||
77 | 75 | 210 | 91 | ||||
Test Chemical | 2,4-Diaminoanisole sulfate |
10 |
32 | 18 | 169 | 176 | 146* |
61 | 35 | 212 | 116 | ||||
15 |
63 | 35 | 218 | 115 | 135* | ||
64 | 33 | 299 | 155 | ||||
20 |
46 | 21 | 151 | 109 | 125* | ||
37 | 21 | 158 | 141 | ||||
25 |
51 | 26 | 256 | 168 | 170* | ||
53 | 21 | 276 | 172 | ||||
30 |
42 | 19 | 221 | 174 | 174* | ||
35 | 20 | 182 | 174 | ||||
40 |
35 | 17 | 171 | 164 | 154* | ||
58 | 28 | 252 | 144 | ||||
Positive Control | 3-Methylcholanthrene |
5 |
41 | 14 | 521 | 424 | 433* |
48 | 15 | 635 | 443 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
83 | 105 | 89 | 36 | 32 |
87 | 96 | 78 | 30 | ||||
85 | 109 | 75 | 30 | ||||
87 | 90 | 86 | 33 | ||||
Test Chemical | 2,4-Diaminoanisole sulfate |
12.5 |
100 | 88 | 219 | 73 | 77* |
81 | 89 | 198 | 81 | ||||
25 |
79 | 92 | 202 | 85 | 81* | ||
76 | 66 | 176 | 77 | ||||
50 |
76 | 73 | 137 | 60 | 64* | ||
64 | 42 | 131 | 69 | ||||
75 |
82 | 32 | 238 | 97 | 136* | ||
63 | 26 | 331 | 175 | ||||
100 |
75 | 19 | 242 | 108 | 102* | ||
86# | 29 | 247 | 96 | ||||
150 |
|||||||
Positive Control | 3-Methylcholanthrene |
5 |
39# | 10 | 366 | 317 | 504* |
22 | 4 | 337 | 518 | ||||
23 | 4 | 464 | 677 |