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Study Information
Study Attribute Value
CEBS Accession Number: 002-01128-0002-0000-6
Chemical Name: 1-Nitronaphthalene
CASRN: 86-57-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 153730_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/18/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 1-Nitronaphthalene 
5         
 100 7 0.070 6.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0 
16         
 100 11 0.110 8.0 3 0.030 3.0 8 0.080 5.0 0 0.000 0.0 
50         
 100 11 0.110 10.0 1 0.010 1.0 10 0.100 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 16 0.320 24.0 8 0.160 14.0 8 0.160 12.0 0 0.000 0.0
Trend: 1.753 0.003 1.902  
Probability: 0.040 0.499 0.029  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/18/1983    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 1-Nitronaphthalene 
5         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
16         
 100 12 0.120 9.0 1 0.010 1.0 11 0.110 9.0 0 0.000 0.0 
50         
 100 32 0.320 25.0 10 0.100 10.0 22 0.220 17.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 14 0.280 26.0 4 0.080 8.0 10 0.200 20.0 0 0.000 0.0
Trend: 4.709 3.395 3.685  
Probability: 0.000 0.000 0.000